Ph.D., Biomedical Sciences2014–2023
Hangang National University · Seoul, Republic of Korea
Mapping Dendritic Cell Heterogeneity Across Chronic Inflammatory Contexts · Advisor: Min-Ho Suh, M.D., Ph.D.
Curriculum Vitae
Emmett Brown, Ph.D.
Computational biologist · single-cell & spatial multi-omics moving into connectome-scale neuroscience
01Profile
Moving from wet-lab immunology into computational neuroscience. I build methods that infer cellular identity, state, and interaction from large, incomplete single-cell and spatial data. Research objective: connect molecular cell identity to circuit structure and function by integrating connectomics with transcriptomics, growing into connectome-constrained circuit models.
02Education
M.S., Biomedical Sciences2012–2014
Hangang National University · Seoul
B.S., Genetic Engineering2008–2012
Suwon Institute of Life Sciences · Suwon
03Research & Professional Experience
Postdoctoral Researcher2025–2026
Nakdong University Wonju College of Medicine · Physiology / Cellular Systems Research Center
Developed deep-learning multimodal-integration models fusing imaging, transcriptomic, and clinical data into single predictive models.
Associate Director, Basic Research2023–2025
Meridian Immune Therapeutics Inc. · Seoul
Built in-house single-cell & spatial transcriptomics analysis code from scratch; led cross-functional NHP (cynomolgus, marmoset) EAE/MS multi-omic studies; oversaw regulatory documentation for an anti-CD25 humanized-antibody program.
Manager, Basic Research2021–2023
Meridian Immune Therapeutics Inc. · Seoul
Researcher2019–2021
Xenotransplantation Center, HNU · Seoul
Research Student · MOSAIC2020–2023
Multi-Organ Single-cell Atlas of Immune Cells, HNU · Genomic Medicine Institute
Contributed the founding proposal; executed within the funded program (500+ donors × 6 organs): milestone tracking, multi-site QC, multi-PI coordination.
04Selected Publications
1Reyes M*, Brown E*, Alvarez T*, et al. "Conserved PDE9X short-isoform bias defines pathogenic Th1.17 state across human inflammatory diseases." Nature Immunology IF 27.7 · under review 2026. Custom UMI-aware BAM-level analysis (Python); consensus NMF; scRNA + scTCR + snATAC integration; disease-state ML classifier AUC 0.812; 588 samples, 19 diseases, 214,300 memory CD4⁺ T cells.
2Brown E*, Tanaka Y*, Truong P*, et al. "Immune cell-enriched scRNA-seq unveils infiltrated CD8⁺ T resident memory cells and meningeal lymphatic endothelium in Parkinson's disease." Journal of Neuroimmunology IF 2.9 · 2025. 9,240 cells, 8 immune populations.
3Brown E*, Delgado J*, Moreau S, et al. "Deciphering Dysfunctional Regulatory T Cells in Vitiligo." Allergy IF 12.6 · 2025.
4Alvarez J*, Brown E*, et al. "Long-term control of diabetes by a baricitinib-based immunosuppressive regimen after allo-islet transplantation in diabetic rhesus monkeys." Xenotransplantation IF 3.9 · 2024.
5Novak L*, Brown E*, et al. "Intra-tumoral heterogeneity and immune escape of melanoma arising from chronic UV photodamage revealed by spatial gene expression profiling." JEADV IF 9.2 · 2022.
6Brown E*, et al. "mTOR inhibitor-based immunosuppression in allogeneic islet transplantation." Islets IF 2.2 · 2019. Co-author, selected: eBioMedicine (2024), JEADV (2024), Current Diabetes Reports (2021).
05Technical Skills
Single-cell / spatial / multi-omicscRNA-seq, scTCR-seq, snRNA/snATAC; Seurat, Scanpy, Squidpy, Monocle3, CellChat/NicheNet; scVI/scANVI, consensus NMF; custom UMI-aware BAM-level isoform code (Python); Milo, GLIPH, InferCNV; GeoMx DSP; Olink proteomics.
Machine learning / DL / AIPython (scikit-learn, XGBoost/LightGBM/CatBoost, PyTorch); AUC-validated classifiers; VAE/GAN/GNN; multimodal DL (imaging + transcriptomic + clinical); AlphaFold2/3, ProteinMPNN, DiffDock; Linux, R, Git.
Experimental (domain ground truth)10x 5′/3′ scRNA + scTCR libraries; high-dimensional flow cytometry (24 markers, 10-color FACS); brain/CNS immune profiling (perfusion, Percoll, CD45⁺ FACS); IHC/IF; two-photon microscopy; NHP CNS tissue (rhesus, cynomolgus, marmoset); EAE/MS & islet-transplant models.
06Awards, Patents & Scholarships
PatentAntagonistic Anti-CD25 Humanized Antibody2024
PatentImmunosuppression w/ PI3K Inhibitor2019
AwardGrand Prize, AI Builders Hackathon2024
AwardGrand Prize, Metro Innovation Workathon2023
AwardBest Poster, ATC Chicago; KAI Best Presentation2017
ScholarNRF Ph.D. · BK21 Plus · HNU Dean's2014–20
07References
Min-Ho Suh, M.D., Ph.D.
HNU College of Medicine; CEO/CSO, Meridian Immune. Ph.D. advisor.
mhsuh@hangang.ac.krJi-Won Baek, M.D., Ph.D.
HNU, Microbiology & Immunology / IBRI. Computational co-corresponding.
jwbaek@hangang.ac.kr