Ph.D., Biomedical Sciences2014–2023
Hangang National University · Seoul, Korea
Mapping Dendritic Cell Heterogeneity Across Chronic Inflammatory Contexts. Advisor: Min-Ho Suh, M.D., Ph.D.
Curriculum Vitae · 2026
Postdoctoral Applicant
LexLuthor.
Computational biologist moving from single-cell and spatial multi-omics into connectome-scale neuroscience
18
Papers
17
Peer-reviewed
6
First / co-first
1
Under review
Profile 00
Moving from wet-lab immunology into computational neuroscience. I build methods that infer cellular identity, state, and interaction from large, incomplete single-cell and spatial data. My objective is to connect molecular cell identity to circuit structure and function by integrating connectomics with transcriptomics, growing into connectome-constrained circuit models.
Education 01
M.S., Biomedical Sciences2012–2014
Hangang National University · Seoul
Enhanced LPS-Induced Monocyte Activation by Recombinant Human Soluble CD180.
B.S., Genetic Engineering2008–2012
Suwon Institute of Life Sciences · Suwon
Experience 02
Postdoctoral Researcher2025–2026
Nakdong Wonju College of Medicine · Physiology / Organelle Medicine RC
Deep-learning multimodal-integration models fusing imaging, transcriptomic, and clinical data into single predictive models.
Associate Director2023–2025
Meridian Immune Therapeutics · Basic Research, Seoul
Built in-house single-cell and spatial code from scratch; led NHP (cynomolgus, marmoset) EAE/MS multi-omic studies; oversaw regulatory docs for an anti-CD25 humanized-antibody program.
Manager · Meridian Immune Therapeutics2021–2023
Basic Research, Seoul
Researcher · Xenotransplant Center, HNU2019–2021
Rhesus macaque tissue processing, longitudinal immune monitoring, CNS tissue handling.
Research Student · MOSAIC, HNU2020–2023
Founding proposal; executed in the funded program (500+ donors × 6 organs): milestone tracking, multi-site QC, multi-PI coordination.
Selected Publications 03
1Reyes M*, Luthor L*, Alvarez T*, et al. "Conserved PDE9X short-isoform bias defines pathogenic Th1.17 state across human inflammatory diseases." Nature Immunology IF 27.7 · under review 2026. UMI-aware BAM-level isoform analysis; scRNA + scTCR + snATAC; ML classifier AUC 0.812; 702 samples, 251,055 CD4⁺ T cells.
2Luthor L*, Tanaka Y*, Truong P*, et al. "Infiltrated CD8⁺ T resident memory cells and meningeal lymphatic endothelium in Parkinson's disease." J. Neuroimmunology IF 2.9 · 2025. 9,240 cells, 8 immune populations.
3Luthor L*, Delgado J*, Moreau S, et al. "Deciphering Dysfunctional Regulatory T Cells in Vitiligo." Allergy IF 12.6 · 2025.
4Alvarez J*, Luthor L*, et al. "Long-term control of diabetes by a baricitinib-based regimen after allo-islet transplantation in rhesus monkeys." Xenotransplantation IF 3.9 · 2024.
5Novak L*, Luthor L*, et al. "Intra-tumoral heterogeneity and immune escape of melanoma from chronic UV photodamage by spatial gene expression." JEADV IF 9.2 · 2022.
6Luthor L*, et al. "mTOR inhibitor-based immunosuppression in allogeneic islet transplantation." Islets IF 2.2 · 2019.
Co-author, selected: eBioMedicine (IF 11.1, 2024) · JEADV (IF 9.2, 2024) · Current Diabetes Reports (IF 4.2, 2021).
Technical Skills 04
Single-cell / spatial / multi-omic
scRNA-seq, scTCR-seq, snRNA/snATAC; Seurat, Scanpy, Squidpy, Monocle3, CellChat/NicheNet; scVI/scANVI, consensus NMF, embedding geometry; custom UMI-aware BAM-level isoform code (Python); Milo, GLIPH, InferCNV, weighted-LMM/EMM; GeoMx DSP; Olink proteomics.
Machine learning / deep learning / AI
Python (scikit-learn, XGBoost/LightGBM/CatBoost, PyTorch); AUC-validated classifiers; VAE/GAN/GNN; multimodal DL (imaging + transcriptomic + clinical); vision-language transformers; AlphaFold2/3, ProteinMPNN, DiffDock, MolFormer; Linux, R, Git.
Experimental (domain ground truth)
10x 5′/3′ scRNA + scTCR libraries; high-dim flow cytometry (24 markers), 10-color FACS; brain/CNS immune profiling; IHC/IF; two-photon; NHP CNS tissue (rhesus, cynomolgus, marmoset); EAE/MS and islet-transplant models.
Languages
Korean (native), English (professional working proficiency).
Awards & Patents 05
Anti-CD25 Humanized Antibody · Patent 10202400918452024
Immunosuppression Composition w/ PI3K Inhibitor2019
Grand Prize, AI Builders Hackathon (Project Nova)2024
Grand Prize, Metro Innovation Workathon2023
Best Poster, American Transplant Congress, Chicago2017
NRF Ph.D. Scholarship · BK21 Plus · HNU Dean's2014–2020
References 06
Min-Ho Suh, M.D., Ph.D.
HNU College of Medicine; CEO/CSO, Meridian Immune. Ph.D. advisor.
mhsuh@hangang.ac.kr
mhsuh@hangang.ac.kr
Ji-Won Baek, M.D., Ph.D.
HNU, Microbiology & Immunology / IBRI. Computational co-corresponding.
jwbaek@hangang.ac.kr
jwbaek@hangang.ac.kr
Dae-Ho Yoon, Ph.D.
Nakdong Wonju, Physiology. Most recent research supervisor.
dhyoon@nakdong.ac.kr
dhyoon@nakdong.ac.kr