Rick Grimes · CV · Vinyl Liner Notes

LP · Postdoctoral Applicant · 2026

Rick Grimes

Computational biologist. Single-cell and spatial multi-omics moving into connectome-scale neuroscience.

Boston, MA 02135T (555) 019-2847E rick.grimes@example.comW rickgrimes.example.com/cvGoogle Scholar

Liner Notes

Moving from wet-lab immunology into computational neuroscience. I build methods that infer cellular identity, state, and interaction from large, incomplete single-cell and spatial data. My objective is to connect molecular cell identity to circuit structure and function by integrating connectomics with transcriptomics, growing into connectome-constrained circuit models.

Side A · Experience

Postdoctoral Researcher

Nakdong Univ. Wonju College of Medicine

2025–26

Deep-learning multimodal-integration models fusing imaging, transcriptomic, and clinical data into single predictive models.

Associate Director

Meridian Immune Therapeutics, Basic Research

2023–25

Built in-house single-cell and spatial transcriptomics code from scratch; led NHP (cynomolgus, marmoset) EAE/MS multi-omic studies; oversaw regulatory docs for an anti-CD25 humanized-antibody program.

Researcher

Xenotransplantation Research Center, HNU

2019–21

Rhesus macaque tissue processing, longitudinal immune monitoring, CNS (brain/spinal cord) tissue handling.

Research Student

MOSAIC, Multi-Organ Single-cell Atlas of Immune Cells, HNU

2020–23

Contributed the founding proposal; executed within the funded program (500+ donors across 6 organs): milestone tracking, multi-site QC, multi-PI coordination.

Pressed On · Education

Ph.D., Biomedical Sciences

Hangang National University

2014–23

Thesis: Mapping Dendritic Cell Heterogeneity Across Chronic Inflammatory Contexts. Advisor: Min-Ho Suh, M.D., Ph.D.

M.S., Biomedical Sciences

Hangang National University

2012–14

Thesis: Enhanced LPS-Induced Monocyte Activation by Recombinant Human Soluble CD180.

B.S., Genetic Engineering

Suwon Institute of Life Sciences, Suwon

2008–12

Credits · Skills

Single-cell / spatial / multi-omicscRNA-seq, scTCR-seq, snRNA/snATAC; Seurat, Scanpy, Squidpy, Monocle3, CellChat/NicheNet; scVI/scANVI, consensus NMF; custom UMI-aware BAM-level isoform code (Python); Milo, GLIPH, InferCNV; GeoMx DSP; Olink proteomics.

Machine learning / deep learning / AIPython (scikit-learn, XGBoost/LightGBM/CatBoost, PyTorch); AUC-validated classifiers; VAE/GAN/GNN; multimodal DL (imaging + transcriptomic + clinical); AlphaFold2/3, ProteinMPNN, DiffDock; Linux, R, Git.

Experimental10x 5′/3′ scRNA + scTCR libraries; high-dim flow cytometry (24 markers); brain/CNS immune profiling; IHC/IF; two-photon; NHP CNS tissue (rhesus, cynomolgus, marmoset); EAE/MS and islet-transplant models.

Side B · Selected Works

18 total17 reviewed6 first/co-first1 in review

Reyes M*, Grimes R*, Alvarez T*, et al. "Conserved PDE9X short-isoform bias defines pathogenic Th1.17 state across human inflammatory diseases." Nature Immunology IF 27.7 · under review, 2026. UMI-aware BAM-level isoform analysis; scRNA + scTCR + snATAC; ML classifier AUC 0.812; 702 samples, 251,055 CD4⁺ T cells.

Grimes R*, Tanaka Y*, Truong P*, et al. "Immune cell-enriched scRNA-seq unveils infiltrated CD8⁺ T resident memory cells and meningeal lymphatic endothelium in Parkinson's disease." Journal of Neuroimmunology IF 2.9 · 2025. 9,240 cells, 8 immune populations.

Grimes R*, Delgado J*, Moreau S, et al. "Deciphering Dysfunctional Regulatory T Cells in Vitiligo." Allergy IF 12.6 · 2025.

Alvarez J*, Grimes R*, et al. "Long-term control of diabetes by a baricitinib-based regimen after allo-islet transplantation in rhesus monkeys." Xenotransplantation IF 3.9 · 2024.

Novak L*, Grimes R*, et al. "Intra-tumoral heterogeneity and immune escape of melanoma from chronic UV photodamage by spatial gene expression." JEADV IF 9.2 · 2022.

Grimes R*, et al. "mTOR inhibitor-based immunosuppression in allogeneic islet transplantation." Islets IF 2.2 · 2019.

Co-author, selected: eBioMedicine (IF 11.1, 2024) · JEADV (IF 9.2, 2024) · Current Diabetes Reports (IF 4.2, 2021).