Immunologist Turns to Computation, Charts Course for Connectome-Scale Neuroscience

A decade of single-cell and spatial multi-omics, now aimed at circuit structure and function

Correspondence · (555) 019-2847 · monica.geller@example.com · Google Scholar · monicageller.example.com/cv

Lead Story · Profile

Moving from wet-lab immunology into computational neuroscience, this vita records methods that infer cellular identity, state, and interaction from large, incomplete single-cell and spatial data. The stated research objective: connect molecular cell identity to circuit structure and function by integrating connectomics with transcriptomics, growing into connectome-constrained circuit models.

Education

Ph.D., Biomedical Sciences

Hangang National University · 2014–2023

Mapping Dendritic Cell Heterogeneity Across Chronic Inflammatory Contexts. Advisor: Min-Ho Suh, M.D., Ph.D.

M.S., Biomedical Sciences

Hangang National University · 2012–2014

Enhanced LPS-Induced Monocyte Activation by Recombinant Human Soluble CD180.

B.S., Genetic Engineering

Suwon Institute of Life Sciences · 2008–2012

Appointments

Postdoctoral Researcher

Nakdong Univ. Wonju · 2025–2026

Deep-learning multimodal-integration models fusing imaging, transcriptomic, and clinical data into single predictive models.

Associate Director

Meridian Immune Therapeutics · 2023–2025

Built in-house single-cell and spatial analysis code from scratch; led NHP (cynomolgus, marmoset) EAE/MS multi-omic studies; anti-CD25 humanized-antibody program documentation.

Researcher

Xenotransplantation Center, HNU · 2019–2021

Rhesus macaque tissue processing, longitudinal immune monitoring, CNS tissue handling.

Research Student, MOSAIC

Genomic Medicine Inst., HNU · 2020–2023

Founding proposal; 500+ donors × 6 organs; multi-site QC and multi-PI coordination.

Publications

18 total · 17 peer-reviewed · 6 first / co-first · 1 under review

1Reyes M*, Geller M*, Alvarez T*, et al. "Conserved PDE9X short-isoform bias defines pathogenic Th1.17 state across human inflammatory diseases." Nature Immunology IF 27.7 · under review 2026. UMI-aware BAM-level isoform analysis; scRNA + scTCR + snATAC; ML classifier AUC 0.812; 702 samples, 251,055 CD4⁺ T cells.

2Geller M*, Tanaka Y*, Truong P*, et al. "Infiltrated CD8⁺ T resident memory cells and meningeal lymphatic endothelium in Parkinson's disease." J. Neuroimmunology IF 2.9 · 2025. 11,587 cells.

3Geller M*, Delgado J*, Moreau S, et al. "Deciphering Dysfunctional Regulatory T Cells in Vitiligo." Allergy IF 12.6 · 2025.

4Alvarez J*, Geller M*, et al. "Long-term control of diabetes by a baricitinib-based regimen after allo-islet transplantation in rhesus monkeys." Xenotransplantation IF 3.9 · 2024.

5Novak L*, Geller M*, et al. "Intra-tumoral heterogeneity and immune escape of melanoma from chronic UV photodamage." JEADV IF 9.2 · 2022.

6Geller M*, et al. "mTOR inhibitor-based immunosuppression in allogeneic islet transplantation." Islets IF 2.2 · 2019. Co-author: eBioMedicine 2024, JEADV 2024, Curr. Diabetes Reports 2021.

Technical Skills

Single-cell / spatial / multi-omicscRNA-seq, scTCR-seq, snRNA/snATAC; Seurat, Scanpy, Squidpy, Monocle3, CellChat/NicheNet; scVI/scANVI, consensus NMF; custom UMI-aware BAM-level isoform code (Python); Milo, GLIPH, InferCNV; GeoMx DSP; Olink.

Machine learning / DL / AIPython (scikit-learn, XGBoost/LightGBM/CatBoost, PyTorch); AUC-validated classifiers; VAE/GAN/GNN; multimodal DL (imaging + transcriptomic + clinical); AlphaFold2/3, ProteinMPNN, DiffDock; Linux, R, Git.

Experimental10x 5′/3′ scRNA + scTCR; flow cytometry (24 markers); brain/CNS immune profiling; IHC/IF; two-photon; NHP CNS tissue; EAE/MS and islet models.

Honours & Patents

Patent: Anti-CD25 Humanized Antibody2024
Patent: Immunosuppression w/ PI3K Inhibitor2019
Grand Prize, AI Builders Hackathon (Nova)2024
Grand Prize, Metro Innovation Workathon2023
Best Poster, Amer. Transplant Congress2017
NRF Ph.D. · BK21 Plus · HNU Dean's2014–20

References

Min-Ho Suh, M.D., Ph.D.

HNU College of Medicine; CEO/CSO, Meridian Immune. Ph.D. advisor.

mhsuh@hangang.ac.kr

Ji-Won Baek, M.D., Ph.D.

HNU, Microbiology & Immunology / IBRI. Computational co-corresponding.

jwbaek@hangang.ac.kr

Dae-Ho Yoon, Ph.D.

Nakdong Wonju, Physiology. Recent research supervisor.

dhyoon@nakdong.ac.kr

Korean (native) · English (professional working) Printed in Boston · All facts as reported Continued upon request