Ph.D., Biomedical Sciences2014–2023
Hangang National University · Seoul
Mapping Dendritic Cell Heterogeneity Across Chronic Inflammatory Contexts. Advisor: Min-Ho Suh.
Curriculum Vitae · Computational Biology
Seong-Jun
Balboa
Ph.D.
Balboa
Computational biologist working in single-cell and spatial multi-omics, moving into connectome-scale neuroscience.
Boston, MA
(555) 019-2847
rocky.balboa@example.com
Google Scholar
Profile
Moving from wet-lab immunology into computational neuroscience. I build methods that infer cellular identity, state, and interaction from large, incomplete single-cell and spatial data. Research objective: connect molecular cell identity to circuit structure and function by integrating connectomics with transcriptomics, growing into connectome-constrained circuit models.
Education
M.S., Biomedical Sciences2012–2014
Hangang National University · Seoul
Enhanced LPS-Induced Monocyte Activation by Recombinant Human Soluble CD180.
B.S., Genetic Engineering2008–2012
Suwon Institute of Life Sciences · Suwon
Experience
Postdoctoral Researcher2025–2026
Nakdong Univ. Wonju College of Medicine · Physiology
Deep-learning multimodal-integration models fusing imaging, transcriptomic, and clinical data.
Associate Director2023–2025
Meridian Immune Therapeutics Inc. · Basic Research
Built single-cell & spatial code from scratch; led NHP EAE/MS multi-omic studies; anti-CD25 regulatory documentation.
Researcher2019–2021
Xenotransplantation Research Center, HNU
Rhesus tissue processing, longitudinal immune monitoring, CNS tissue handling.
Research Student · MOSAIC2020–2023
Genomic Medicine Institute, HNU
Founding proposal; funded program of 500+ donors × 6 organs: QC, milestone tracking, multi-PI coordination.
Selected Publications
01Reyes M*, Balboa R*, Alvarez T*, et al. "Conserved PDE9X short-isoform bias defines pathogenic Th1.17 state across human inflammatory diseases." Nature Immunology IF 27.7 · under review (2026). UMI-aware BAM-level isoform analysis; scRNA + scTCR + snATAC integration; ML classifier AUC 0.812; 702 samples, 251,055 CD4⁺ T cells.
02Balboa R*, Tanaka Y*, Truong P*, et al. "Immune cell-enriched scRNA-seq unveils infiltrated CD8⁺ T resident memory cells and meningeal lymphatic endothelium in Parkinson's disease." Journal of Neuroimmunology IF 2.9 · 2025. 9,240 cells, 8 immune populations.
03Balboa R*, Delgado J*, Moreau S, et al. "Deciphering Dysfunctional Regulatory T Cells in Vitiligo." Allergy IF 12.6 · 2025.
04Alvarez J*, Balboa R*, et al. "Long-term control of diabetes by a baricitinib-based regimen after allo-islet transplantation in rhesus monkeys." Xenotransplantation IF 3.9 · 2024.
05Novak L*, Balboa R*, et al. "Intra-tumoral heterogeneity and immune escape of melanoma from chronic UV photodamage by spatial gene expression." JEADV IF 9.2 · 2022. Co-author: eBioMedicine (2024), JEADV (2024), Curr. Diabetes Reports (2021).
Technical Skills
Single-cell / spatial / multi-omicscRNA-seq, scTCR-seq, snRNA/snATAC; Seurat, Scanpy, Squidpy, Monocle3, CellChat/NicheNet; scVI/scANVI, consensus NMF; custom UMI-aware BAM-level isoform code (Python); Milo, GLIPH, InferCNV; GeoMx DSP; Olink proteomics.
Machine learning / DL / AIPython (scikit-learn, XGBoost/LightGBM/CatBoost, PyTorch); AUC-validated classifiers; VAE/GAN/GNN; multimodal DL (imaging + transcriptomic + clinical); AlphaFold2/3, ProteinMPNN, DiffDock; Linux, R, Git.
Experimental10x 5′/3′ scRNA + scTCR libraries; high-dim flow cytometry (24 markers); brain/CNS immune profiling; IHC/IF; two-photon; NHP CNS tissue (rhesus, cynomolgus, marmoset); EAE/MS & islet-transplant models.
Awards & Patents
Anti-CD25 Humanized Antibody (Patent)2024
PI3K Inhibitor Immunosuppression (Patent)2019
Grand Prize, AI Builders Hackathon2024
Grand Prize, Metro Innovation Workathon2023
Best Poster, Amer. Transplant Congress2017
NRF Ph.D. · BK21 Plus · HNU Dean's14–20