seong-jun-kang · cv · zsh · 120×48 ~/cv/seong-jun-kang.md
sjkang@boston:~$ whoami --profile
Sherlock Holmes, Ph.D.
Computational single-cell scientist · single-cell & spatial multi-omics → connectome-scale neuroscience
location = "Boston, MA"
phone = "(555) 019-2847"
email = "sherlock.holmes@example.com"
scholar = "scholar.google.com" · site = "sherlockholmes.example.com/cv"
sjkang@boston:~$ cat profile.txt

Moving from wet-lab immunology into computational neuroscience. I build methods that infer cellular identity, state, and interaction from large, incomplete single-cell and spatial data. Objective: connect molecular cell identity to circuit structure and function by integrating connectomics with transcriptomics, growing into connectome-constrained circuit models.
interests: single-cell & spatial multi-omics · cell-type inference from incomplete data · self-supervised representation learning · connectome × transcriptomics · computational neuroimmunology

sjkang@boston:~$ ls -la ./education
degreeinstitutionyears
Ph.D., Biomedical SciencesThesis: Mapping Dendritic Cell Heterogeneity Across Chronic Inflammatory Contexts · Advisor: Min-Ho Suh, M.D., Ph.D.Hangang National University2014–2023
M.S., Biomedical SciencesThesis: Enhanced LPS-Induced Monocyte Activation by Recombinant Human Soluble CD180.Hangang National University2012–2014
B.S., Genetic EngineeringSuwon Institute of Life Sciences, Suwon2008–2012
sjkang@boston:~$ git log --oneline ./experience
roleorganizationperiod
Postdoctoral ResearcherDeep-learning multimodal-integration models fusing imaging, transcriptomic, and clinical data into single predictive models.Nakdong Univ. Wonju, Physiology / Organelle Medicine RC2025–2026
Associate DirectorBuilt in-house single-cell & spatial transcriptomics code from scratch; led NHP (cynomolgus, marmoset) EAE/MS multi-omic studies; oversaw regulatory docs for an anti-CD25 humanized-antibody program.Meridian Immune Therapeutics, Basic Research2023–2025
ResearcherRhesus macaque tissue processing, longitudinal immune monitoring, CNS (brain/spinal cord) tissue handling.Xenotransplantation Research Center, HNU2019–2021
Research Student, MOSAICFounding proposal + execution in funded program (500+ donors, 6 organs): milestone tracking, multi-site QC, multi-PI coordination.Genomic Medicine Institute, HNU2020–2023
sjkang@boston:~$ grep -c "Holmes S" ./publications
18 total17 peer-reviewed6 first / co-first1 under review
01Reyes M*, Holmes S*, Alvarez T*, et al. "Conserved PDE9X short-isoform bias defines pathogenic Th1.17 state across human inflammatory diseases." Nature Immunology IF 27.7 under review. UMI-aware BAM-level isoform analysis; scRNA + scTCR + snATAC; ML classifier AUC 0.812; 702 samples, 251,055 CD4⁺ T cells.2026
02Holmes S*, Tanaka Y*, Truong P*, et al. "Immune cell-enriched scRNA-seq unveils infiltrated CD8⁺ Trm cells and meningeal lymphatic endothelium in Parkinson's disease." J. Neuroimmunology IF 2.9. 9,240 cells, 8 immune populations.2025
03Holmes S*, Delgado J*, Moreau S, et al. "Deciphering Dysfunctional Regulatory T Cells in Vitiligo." Allergy IF 12.6.2025
04Alvarez J*, Holmes S*, et al. "Long-term control of diabetes by a baricitinib-based regimen after allo-islet transplantation in rhesus monkeys." Xenotransplantation IF 3.9.2024
05Novak L*, Holmes S*, et al. "Intra-tumoral heterogeneity and immune escape of melanoma from chronic UV photodamage by spatial gene expression." JEADV IF 9.2.2022
06Holmes S*, et al. "mTOR inhibitor-based immunosuppression in allogeneic islet transplantation." Islets IF 2.2. Co-author: eBioMedicine (2024), JEADV (2024), Curr. Diabetes Reports (2021).2019
sjkang@boston:~$ env | grep SKILLS
SC_SPATIAL=scRNA-seq, scTCR-seq, snRNA/snATAC; Seurat, Scanpy, Squidpy, Monocle3, CellChat/NicheNet; scVI/scANVI, consensus NMF; custom UMI-aware BAM-level isoform code (Python); Milo, GLIPH, InferCNV; GeoMx DSP; Olink proteomics. ML_DL_AI=Python (scikit-learn, XGBoost/LightGBM/CatBoost, PyTorch); AUC-validated classifiers; VAE/GAN/GNN; multimodal DL (imaging + transcriptomic + clinical); AlphaFold2/3, ProteinMPNN, DiffDock; Linux, R, Git. WET_LAB=10x 5′/3′ scRNA + scTCR libraries; high-dim flow cytometry (24 markers); brain/CNS immune profiling; IHC/IF; two-photon; NHP CNS tissue (rhesus, cynomolgus, marmoset); EAE/MS & islet-transplant models.
sjkang@boston:~$ cat awards.log patents.log
Anti-CD25 Humanized Antibody (Patent)2024
Immunosuppression w/ PI3K Inhibitor (Patent)2019
Grand Prize, AI Builders Hackathon (Nova)2024
Grand Prize, Metro Innovation Workathon2023
Best Poster, American Transplant Congress2017
NRF Ph.D. · BK21 Plus · HNU Dean's2014–2020
sjkang@boston:~$ cat references.json
Min-Ho Suh, M.D., Ph.D.
HNU College of Medicine; CEO/CSO, Meridian Immune. Ph.D. advisor.
mhsuh@hangang.ac.kr
Ji-Won Baek, M.D., Ph.D.
HNU, Microbiology & Immunology / IBRI. Computational co-corresponding.
jwbaek@hangang.ac.kr
Dae-Ho Yoon, Ph.D.
Nakdong Wonju, Physiology. Recent research supervisor.
dhyoon@nakdong.ac.kr
sjkang@boston:~$ exit