Ph.D., Biomedical Sciences2014–23
Hangang National University · Seoul, Korea
Dendritic Cell Heterogeneity Across Chronic Inflammatory Contexts. Advisor: Min-Ho Suh, M.D., Ph.D.
Scott Lang Ph.D.
Computational biologist moving from single-cell and spatial multi-omics into connectome-scale neuroscience.
Profile
Moving from wet-lab immunology into computational neuroscience. I build methods that infer cellular identity, state, and interaction from large, incomplete single-cell and spatial data. Research objective: connect molecular cell identity to circuit structure and function by integrating connectomics with transcriptomics, growing into connectome-constrained circuit models.
Education
M.S., Biomedical Sciences2012–14
Hangang National University · Seoul
LPS-induced monocyte activation by recombinant human soluble CD180.
B.S., Genetic Engineering2008–12
Suwon Institute of Life Sciences · Suwon
Experience
Postdoctoral Researcher2025–26
Nakdong Univ. Wonju College of Medicine · Physiology
Deep-learning multimodal-integration models fusing imaging, transcriptomic, and clinical data into single predictive models.
Associate Director2023–25
Meridian Immune Therapeutics Inc. · Seoul
Built in-house single-cell and spatial transcriptomics code; led NHP (cynomolgus, marmoset) EAE/MS multi-omic studies; anti-CD25 antibody regulatory documentation.
Researcher2019–21
Xenotransplantation Research Center, HNU
Rhesus macaque tissue processing, longitudinal immune monitoring, CNS tissue handling.
Research Student2020–23
MOSAIC, Multi-Organ Single-cell Atlas of Immune Cells, HNU
Founding proposal; funded program (500+ donors × 6 organs): milestone tracking, multi-site QC, multi-PI coordination.
Selected Publications
Reyes M*, Lang S*, Alvarez T*, et al. "Conserved PDE9X short-isoform bias defines pathogenic Th1.17 state across human inflammatory diseases." Nature Immunology IF 27.7 · under review 2026. UMI-aware BAM isoform analysis; scRNA + scTCR + snATAC integration; ML classifier AUC 0.812; 702 samples, 251,055 CD4⁺ T cells.
Lang S*, Tanaka Y*, Truong P*, et al. "Immune cell-enriched scRNA-seq unveils infiltrated CD8⁺ T resident memory cells and meningeal lymphatic endothelium in Parkinson's disease." Journal of Neuroimmunology IF 2.9 · 2025. 9,240 cells, 8 immune populations.
Lang S*, Delgado J*, Moreau S, et al. "Deciphering Dysfunctional Regulatory T Cells in Vitiligo." Allergy IF 12.6 · 2025.
Alvarez J*, Lang S*, et al. "Long-term control of diabetes by a baricitinib-based regimen after allo-islet transplantation in rhesus monkeys." Xenotransplantation IF 3.9 · 2024.
Novak L*, Lang S*, et al. "Intra-tumoral heterogeneity and immune escape of melanoma from chronic UV photodamage by spatial gene expression." JEADV IF 9.2 · 2022.
Lang S*, et al. "mTOR inhibitor-based immunosuppression in allogeneic islet transplantation." Islets IF 2.2 · 2019. Co-author: eBioMedicine (2024), JEADV (2024), Curr. Diabetes Reports (2021).
Technical Skills
Single-cell / spatial / multi-omic. scRNA-seq, scTCR-seq, snRNA/snATAC; Seurat, Scanpy, Squidpy, Monocle3, CellChat/NicheNet; scVI/scANVI, consensus NMF; custom UMI-aware BAM-level isoform code (Python); Milo, GLIPH, InferCNV; GeoMx DSP; Olink proteomics.
Machine learning / DL / AI. Python (scikit-learn, XGBoost/LightGBM/CatBoost, PyTorch); AUC-validated classifiers; VAE/GAN/GNN; multimodal DL (imaging + transcriptomic + clinical); AlphaFold2/3, ProteinMPNN, DiffDock; Linux, R, Git.
Experimental. 10x 5′/3′ scRNA + scTCR libraries; high-dim flow cytometry (24 markers); brain/CNS immune profiling; IHC/IF; two-photon; NHP CNS tissue (rhesus, cynomolgus, marmoset); EAE/MS and islet-transplant models.
Awards, Patents & Scholarships
Patent 2024. Antagonistic anti-CD25 humanized antibody (No. 1020240091845).
Patent 2019. Immunosuppression composition with JAK inhibitor (No. 1020143496217).
2024. Grand Prize, AI Builders Hackathon (Project Nova).
2023. Grand Prize, Metro Innovation Workathon.
2017. Best Poster, American Transplant Congress, Chicago.
2014–2020. NRF Ph.D. Scholarship, BK21 Plus, HNU Dean's.
References
Min-Ho Suh, M.D., Ph.D.
HNU College of Medicine; CEO/CSO, Meridian Immune. Ph.D. advisor.
mhsuh@hangang.ac.krJi-Won Baek, M.D., Ph.D.
HNU, Microbiology & Immunology / IBRI. Computational co-corresponding.
jwbaek@hangang.ac.kr