Curriculum Vitae
Stephen Strange, Ph.D.
Computational biologist · Single-cell & spatial multi-omics into connectome-scale neuroscience
Boston, MA ◆ (555) 019-2847 ◆ stephen.strange@example.com ◆ Google Scholar
Profile
Moving from wet-lab immunology into computational neuroscience. I build methods that infer cellular identity, state, and interaction from large, incomplete single-cell and spatial data. Objective: connect molecular cell identity to circuit structure and function by integrating connectomics with transcriptomics, growing into connectome-constrained circuit models.
Experience
Postdoctoral Researcher
Nakdong University Wonju College of Medicine · Physiology / Cellular Systems Research Center
2025–2026
Developed deep-learning multimodal-integration models fusing imaging, transcriptomic, and clinical data into single predictive models.
Associate Director
Meridian Immune Therapeutics Inc. · Basic Research, Seoul
2023–2025
Built in-house single-cell & spatial transcriptomics code from scratch; led cross-functional NHP (cynomolgus, marmoset) EAE/MS multi-omic studies; oversaw regulatory documentation for an anti-CD25 humanized-antibody program.
Researcher, Xenotransplantation Research Center, HNU
Seoul · with Research Student, MOSAIC (2020–2023)
2019–2021
Rhesus macaque tissue processing, longitudinal immune monitoring, CNS tissue handling. MOSAIC: founding proposal; funded program of 500+ donors × 6 organs with multi-site QC and multi-PI coordination.
Education
Ph.D.
Biomedical Sciences
Hangang National University. Regulatory T-cell role in inflammatory contexts. Advisor: Min-Ho Suh.
2014–2023
M.S.
Biomedical Sciences
Hangang National University. sCD180 and LPS-induced monocyte activation.
2012–2014
B.S.
Genetic Engineering
Suwon Institute of Life Sciences, Suwon.
2008–2012
Selected Publications
IReyes M*, Strange S*, Alvarez T*, et al. "Conserved PDE9X short-isoform bias defines pathogenic Th1.17 state across human inflammatory diseases." Nature Immunology IF 27.7 · under review (2026). UMI-aware BAM-level isoform analysis; scRNA + scTCR + snATAC integration; ML classifier AUC 0.812; 702 samples, 251,055 CD4⁺ T cells.
IIStrange S*, Tanaka Y*, Truong P*, et al. "Immune cell-enriched scRNA-seq unveils infiltrated CD8⁺ T resident memory cells and meningeal lymphatic endothelium in Parkinson's disease." Journal of Neuroimmunology IF 2.9 · 2025. 9,240 cells, 8 immune populations.
IIIStrange S*, Delgado J*, Moreau S, et al. "Deciphering Dysfunctional Regulatory T Cells in Vitiligo." Allergy IF 12.6 · 2025.
IVAlvarez J*, Strange S*, et al. "Long-term control of diabetes by a baricitinib-based regimen after allo-islet transplantation in rhesus monkeys." Xenotransplantation IF 3.9 · 2024.
VNovak L*, Strange S*, et al. "Intra-tumoral heterogeneity and immune escape of melanoma from chronic UV photodamage by spatial gene expression." JEADV IF 9.2 · 2022.
VIStrange S*, et al. "mTOR inhibitor-based immunosuppression in allogeneic islet transplantation." Islets IF 2.2 · 2019. Selected co-author: eBioMedicine (2024), JEADV (2024), Curr. Diabetes Reports (2021).
Technical Skills
Single-cell / Spatial / Multi-omicscRNA-seq, scTCR-seq, snRNA/snATAC; Seurat, Scanpy, Squidpy, Monocle3, CellChat/NicheNet; scVI/scANVI, consensus NMF, embedding geometry; custom UMI-aware BAM-level isoform code (Python); Milo, GLIPH, InferCNV; GeoMx DSP; Olink proteomics.
Machine Learning / Deep Learning / AIPython (scikit-learn, XGBoost/LightGBM/CatBoost, PyTorch); AUC-validated classifiers; VAE/GAN/GNN; multimodal DL (imaging + transcriptomic + clinical); vision-language transformers; AlphaFold2/3, ProteinMPNN, DiffDock, MolFormer; Linux, R, Git.
Experimental Ground Truth10x 5′/3′ scRNA + scTCR libraries; high-dimensional flow cytometry (24 markers), 6-way FACS; brain/CNS immune profiling; IHC/IF; two-photon microscopy; NHP CNS tissue (rhesus, cynomolgus, marmoset); EAE/MS and islet-transplant models.
Awards, Patents & Scholarships
Antagonistic Anti-CD25 Humanized Antibody (Patent)2024
Immunosuppression Composition w/ PI3K Inhibitor (Patent)2019
Grand Prize, AI Builders Hackathon (Project Nova)2024
Grand Prize, Metro Innovation Workathon2023
Best Poster, American Transplant Congress, Chicago2017
NRF Ph.D. Scholarship · BK21 Plus · HNU Dean's2014–2020
References
Min-Ho Suh, M.D., Ph.D.
HNU College of Medicine; CEO/CSO, Meridian Immune Therapeutics. Ph.D. advisor.
mhsuh@hangang.ac.krJi-Won Baek, M.D., Ph.D.
HNU, Microbiology & Immunology / IBRI. Computational co-corresponding.
jwbaek@hangang.ac.kr