Profile

Moving from wet-lab immunology into computational neuroscience. I build methods that infer cellular identity, state, and interaction from large, incomplete single-cell and spatial data, connecting molecular cell identity to circuit structure and function.

Skills

Single-cell / spatial
scRNA/scTCR-seq, snRNA/snATAC; Seurat, Scanpy, Squidpy, Monocle3, CellChat/NicheNet; scVI/scANVI, consensus NMF; UMI-aware BAM-level isoform code; Milo, GLIPH, InferCNV; GeoMx DSP; Olink.
ML / DL / AI
Python (scikit-learn, XGBoost/LightGBM/CatBoost, PyTorch); AUC-validated classifiers; VAE/GAN/GNN; multimodal DL (imaging + transcriptomic + clinical); AlphaFold2/3, ProteinMPNN, DiffDock; Linux, R, Git.
Experimental
10x 5′/3′ scRNA + scTCR libraries; 24-marker flow cytometry; brain/CNS immune profiling; IHC/IF; two-photon; NHP CNS tissue (rhesus, cynomolgus, marmoset); EAE/MS and islet models.

Awards & Patents

2024 Antagonistic Anti-CD25 Humanized Antibody (Patent)
2019 Immunosuppression Composition w/ PI3K Inhibitor (Patent)
2024 Grand Prize, AI Builders Hackathon (Project Nova)
2023 Grand Prize, Metro Innovation Workathon
2017 Best Poster, American Transplant Congress, Chicago
2014–2020 NRF Ph.D. Scholarship, BK21 Plus, HNU Dean's

References

Min-Ho Suh, M.D., Ph.D.
HNU College of Medicine; CEO/CSO, Meridian Immune. Ph.D. advisor.
mhsuh@hangang.ac.kr
Ji-Won Baek, M.D., Ph.D.
HNU, Microbiology & Immunology / IBRI. Computational co-corresponding.
jwbaek@hangang.ac.kr
Dae-Ho Yoon, Ph.D.
Nakdong Wonju, Physiology. Recent research supervisor.
dhyoon@nakdong.ac.kr

Education

Ph.D., Biomedical Sciences
Hangang National University · Seoul, Republic of Korea
2014–2023
Thesis: Mapping Dendritic Cell Heterogeneity Across Chronic Inflammatory Contexts. Advisor: Min-Ho Suh, M.D., Ph.D.
M.S., Biomedical Sciences
Hangang National University · Seoul
2012–2014
Thesis: Enhanced LPS-Induced Monocyte Activation by Recombinant Human Soluble CD180.
B.S., Genetic Engineering
Suwon Institute of Life Sciences · Suwon
2008–2012

Experience

Postdoctoral Researcher
Nakdong University Wonju College of Medicine · Physiology / Cellular Systems Research Center
2025–2026
Developed deep-learning multimodal-integration models fusing imaging, transcriptomic, and clinical data into single predictive models.
Associate Director
Meridian Immune Therapeutics Inc. · Basic Research, Seoul
2023–2025
Built in-house single-cell and spatial transcriptomics analysis code from scratch; led cross-functional NHP (cynomolgus, marmoset) EAE/MS multi-omic studies; oversaw regulatory documentation for an anti-CD25 humanized-antibody program.
Researcher
Xenotransplantation Research Center, HNU · Seoul
2019–2021
Rhesus macaque tissue processing, longitudinal immune monitoring, CNS tissue handling.
Research Student, MOSAIC
Multi-Organ Single-cell Atlas of Immune Cells, HNU · Genomic Medicine Institute
2020–2023
Contributed the founding proposal; executed within the funded program (500+ donors across 6 organs): milestone tracking, multi-site QC, multi-PI coordination.

Selected Publications

18total17peer-reviewed6first / co-first1under review
01Reyes M*, Scott M*, Alvarez T*, et al. "Conserved PDE9X short-isoform bias defines pathogenic Th1.17 state across human inflammatory diseases." Nature Immunology IF 27.7 · under review, 2026. UMI-aware BAM-level isoform analysis; scRNA + scTCR + snATAC; ML classifier AUC 0.812; 702 samples, 251,055 CD4⁺ T cells.
02Scott M*, Tanaka Y*, Truong P*, et al. "Immune cell-enriched scRNA-seq unveils infiltrated CD8⁺ T resident memory cells and meningeal lymphatic endothelium in Parkinson's disease." J. Neuroimmunology IF 2.9, 2025. 11,587 cells.
03Scott M*, Delgado J*, Moreau S, et al. "Deciphering Dysfunctional Regulatory T Cells in Vitiligo." Allergy IF 12.6, 2025.
04Alvarez J*, Scott M*, et al. "Long-term control of diabetes by a baricitinib-based regimen after allo-islet transplantation in rhesus monkeys." Xenotransplantation IF 3.9, 2024.
05Novak L*, Scott M*, et al. "Intra-tumoral heterogeneity and immune escape of melanoma from chronic UV photodamage by spatial gene expression." JEADV IF 9.2, 2022.
06Scott M*, et al. "mTOR inhibitor-based immunosuppression in allogeneic islet transplantation." Islets IF 2.2, 2019. Co-author: eBioMedicine (2024), JEADV (2024), Curr. Diabetes Reports (2021).