2014–2023
Ph.D., Biomedical Sciences
Hangang National University · Seoul, Republic of Korea
Thesis: Mapping Dendritic Cell Heterogeneity Across Chronic Inflammatory Contexts. Advisor: Min-Ho Suh, M.D., Ph.D.
Jean-Luc Picard, Ph.D.
Computational biologist · single-cell & spatial multi-omics toward connectome-scale neuroscience
Profile
Moving from wet-lab immunology into computational neuroscience. I build methods that infer cellular identity, state, and interaction from large, incomplete single-cell and spatial data. Research objective: connect molecular cell identity to circuit structure and function by integrating connectomics with transcriptomics, growing into connectome-constrained circuit models.
Education
2012–2014
M.S., Biomedical Sciences
Hangang National University · Seoul
Thesis: Enhanced LPS-Induced Monocyte Activation by Recombinant Human Soluble CD180.
2008–2012
B.S., Genetic Engineering
Suwon Institute of Life Sciences · Suwon
Experience
2025–2026
Postdoctoral Researcher
Nakdong University Wonju College of Medicine · Physiology / Cellular Systems Research Center
Developed deep-learning multimodal-integration models fusing imaging, transcriptomic, and clinical data into single predictive models.
2023–2025
Associate Director
Meridian Immune Therapeutics Inc. · Basic Research, Seoul
Built in-house single-cell & spatial transcriptomics analysis code from scratch; led NHP (cynomolgus, marmoset) EAE/MS multi-omic studies; oversaw regulatory documentation for an anti-CD25 humanized-antibody program.
2019–2021
Researcher
Xenotransplantation Research Center, HNU · Seoul
Rhesus macaque tissue processing, longitudinal immune monitoring, CNS (brain/spinal cord) tissue handling.
2020–2023
Research Student
MOSAIC, Multi-Organ Single-cell Atlas of Immune Cells, HNU · Genomic Medicine Institute
Contributed the founding proposal; executed within the funded program (500+ donors × 6 organs): milestone tracking, multi-site QC, multi-PI coordination.
Selected Publications
Reyes M*, Picard J-L*, Alvarez T*, et al. Conserved PDE9X short-isoform bias defines pathogenic Th1.17 state across human inflammatory diseases. Nature Immunology IF 27.7 · under review, 2026. UMI-aware BAM-level isoform analysis; scRNA + scTCR + snATAC integration; ML classifier AUC 0.812; 702 samples, 251,055 CD4⁺ T cells.
Picard J-L*, Tanaka Y*, Truong P*, et al. Immune cell-enriched scRNA-seq unveils infiltrated CD8⁺ T resident memory cells and meningeal lymphatic endothelium in Parkinson's disease. Journal of Neuroimmunology IF 2.9 · 2025. 9,240 cells, 8 immune populations.
Picard J-L*, Delgado J*, Moreau S, et al. Deciphering Dysfunctional Regulatory T Cells in Vitiligo. Allergy IF 12.6 · 2025.
Alvarez J*, Picard J-L*, et al. Long-term control of diabetes by a baricitinib-based regimen after allo-islet transplantation in rhesus monkeys. Xenotransplantation IF 3.9 · 2024.
Novak L*, Picard J-L*, et al. Intra-tumoral heterogeneity and immune escape of melanoma from chronic UV photodamage by spatial gene expression profiling. JEADV IF 9.2 · 2022.
Picard J-L*, et al. mTOR inhibitor-based immunosuppression in allogeneic islet transplantation. Islets IF 2.2 · 2019.
Selected co-authorships: eBioMedicine (IF 11.1, 2024); JEADV (IF 9.2, 2024); Current Diabetes Reports (IF 4.2, 2021).