Ph.D., Biomedical Sciences, Hangang National University2014–2023
Seoul, Republic of Korea
Thesis: Mapping Dendritic Cell Heterogeneity Across Chronic Inflammatory Contexts. Advisor: Min-Ho Suh, M.D., Ph.D.
Jack Sparrow, Ph.D.
Computational biologist, single-cell & spatial multi-omics toward connectome-scale neuroscience
220 Harbor Street, Boston, MA 02135
T (555) 019-2847
W jacksparrow.example.com/cv
S Google Scholar
Research Summary
Moving from wet-lab immunology into computational neuroscience. I build methods that infer cellular identity, state, and interaction from large, incomplete single-cell and spatial data. My research objective is to connect molecular cell identity to circuit structure and function by integrating connectomics with transcriptomics, growing into connectome-constrained circuit models.
Interests: single-cell & spatial multi-omics; cell-type inference from incomplete data; self-supervised / embedding representation learning; connectome × transcriptomics; computational neuroimmunology; reproducible ML/DL analysis.
Education
M.S., Biomedical Sciences, Hangang National University2012–2014
Thesis: Enhanced LPS-Induced Monocyte Activation by Recombinant Human Soluble CD180. Advisor: Min-Ho Suh, M.D., Ph.D.
B.S., Genetic Engineering, Suwon Institute of Life Sciences2008–2012
Suwon, Republic of Korea
Selected Publications
First / co-first author · * equal contribution
- Reyes M*, Sparrow J*, Alvarez T*, et al. "Conserved PDE9X short-isoform bias defines pathogenic Th1.17 state across human inflammatory diseases." Nature Immunology, IF 27.7, under review (2026). UMI-aware BAM-level isoform analysis; scRNA + scTCR + snATAC integration; disease-state ML classifier, AUC 0.812; cross-disease meta-analysis of 588 samples, 19 diseases, 214,300 memory CD4⁺ T cells.
- Sparrow J*, Tanaka Y*, Truong P*, et al. "Immune cell-enriched single-cell RNA sequencing unveils the interplay between infiltrated CD8⁺ T resident memory cells and meningeal lymphatic endothelial cells in Parkinson's disease." Journal of Neuroimmunology, IF 2.9, 2025. 9,240 cells, 8 immune populations.
- Sparrow J*, Delgado J*, Moreau S, et al. "Deciphering Dysfunctional Regulatory T Cells in Vitiligo." Allergy, IF 12.6, 2025.
- Alvarez J*, Sparrow J*, et al. "Long-term control of diabetes by baricitinib-based immunosuppressive regimen after allo-islet transplantation in diabetic rhesus monkeys." Xenotransplantation, IF 3.9, 2024.
- Novak L*, Sparrow J*, et al. "Intra-tumoral heterogeneity and immune escape of melanoma arising from chronic UV photodamage revealed by spatial gene expression profiling." JEADV, IF 9.2, 2022.
- Sparrow J*, et al. "mTOR inhibitor-based immunosuppression in allogeneic islet transplantation." Islets, IF 2.2, 2019.
Co-author (selected): eBioMedicine (IF 11.1, 2024), high-dimensional profiling of regulatory T cells in lichen planus; JEADV (IF 9.2, 2024), spatial transcriptomics of tumour–immune interactions in photodamage-arising melanoma; Current Diabetes Reports (IF 4.2, 2021), immunomodulatory approaches for porcine islet xenotransplantation.
Research & Professional Experience
Postdoctoral Researcher, Nakdong University Wonju College of Medicine2025–2026
Physiology / Cellular Systems Research Center, Wonju
Developed deep-learning multimodal-integration models fusing imaging, transcriptomic, and clinical data into single predictive models.
Associate Director, Meridian Immune Therapeutics Inc.2023–2025
Basic Research, Seoul
Built in-house single-cell and spatial transcriptomics analysis code from scratch; led cross-functional NHP (cynomolgus, marmoset) EAE/multiple-sclerosis multi-omic studies; oversaw regulatory documentation for an anti-CD25 humanized-antibody program.
Researcher, Xenotransplantation Research Center, HNU2019–2021
Rhesus macaque tissue processing, longitudinal immune monitoring, CNS (brain/spinal cord) tissue handling.
Research Student, MOSAIC, Multi-Organ Single-cell Atlas of Immune Cells, HNU2020–2023
Genomic Medicine Institute
Contributed the founding proposal; executed within the funded program (500+ donors across 6 organs): milestone tracking, multi-site QC, multi-PI coordination.
Teaching Assistant, HNU College of Medicine2014–2016
Microbiology and Immunology
Technical Skills
Single-cell / spatial / multi-omic: scRNA-seq, scTCR-seq, snRNA/snATAC; Seurat, Scanpy, Squidpy, Monocle3, CellChat/NicheNet; scVI/scANVI, batch integration, consensus NMF, embedding geometry; custom UMI-aware BAM-level isoform code (Python); Milo KNN-graph DA, GLIPH, Shannon-entropy clonality, InferCNV, weighted-LMM/EMM; GeoMx DSP (WTA + TCR); Olink targeted plasma proteomics.
Machine learning / deep learning / AI: Python (scikit-learn, XGBoost/LightGBM/CatBoost, PyTorch); AUC-validated classifiers; VAE/GAN/GNN; multimodal DL integration (imaging + transcriptomic + clinical); vision-language transformers; AlphaFold2/3, ProteinMPNN, DiffDock, MolFormer; Linux servers, R/RStudio, Git-based reproducible analysis.
Experimental (domain ground truth): 10x 5′/3′ scRNA + scTCR library generation; high-dimensional flow cytometry (up to 24 markers), 10-color 6-way FACS; brain/CNS immune profiling (perfusion, digestion, Percoll, CD45⁺ FACS); IHC/IF (frozen & FFPE); two-photon microscopy; NHP CNS tissue (rhesus, cynomolgus, marmoset); EAE/MS and islet-transplant disease models.
Awards, Patents & Scholarships
Antagonistic Anti-CD25 Humanized Antibody, Patent No. 10202400918452024
Immunosuppression Composition with PI3K Inhibitor, Patent No. 10201434962172019
Grand Prize, 2024 AI Builders Hackathon (Project Nova Team)2024
Grand Prize, Metro Innovation Workathon (Work Process Innovation)2023
Best Poster, American Transplant Congress, Chicago2017
Best Presentation, Korean Association of Immunologists2017
NRF Research Scholarship for Ph.D. Candidates2014–2020
HNU Dean's Lecture & Research Support · BK21 Plus2014–2020
References
Min-Ho Suh, M.D., Ph.D.
Professor, Microbiology & Immunology / Biomedical Sciences, HNU College of Medicine; CEO/CSO, Meridian Immune Therapeutics. Ph.D. advisor.
mhsuh@hangang.ac.krJi-Won Baek, M.D., Ph.D.
Assistant Professor, Microbiology & Immunology / IBRI, HNU. Co-corresponding, computational / single-cell.
jwbaek@hangang.ac.krDae-Ho Yoon, Ph.D.
Professor, Physiology & Global Medical Science, Nakdong University Wonju College of Medicine. Most recent research supervisor.
dhyoon@nakdong.ac.kr