Ph.D., Biomedical Sciences2014–2023
Hangang National University Seoul, Republic of Korea
Mapping Dendritic Cell Heterogeneity Across Chronic Inflammatory Contexts. Advisor: Min-Ho Suh, M.D., Ph.D.
Luke Skywalker, Ph.D.
Computational biologist, single-cell & spatial multi-omics toward connectome-scale neuroscience
220 Harbor Street, Boston, MA 02135
(555) 019-2847
luke.skywalker@example.com
Google Scholar
Profile 00
Moving from wet-lab immunology into computational neuroscience. I build methods that infer cellular identity, state, and interaction from large, incomplete single-cell and spatial data. Research objective: connect molecular cell identity to circuit structure and function by integrating connectomics with transcriptomics, growing into connectome-constrained circuit models.
Education 01
M.S., Biomedical Sciences2012–2014
Hangang National University Seoul
Enhanced LPS-Induced Monocyte Activation by Recombinant Human Soluble CD180.
B.S., Genetic Engineering2008–2012
Suwon Institute of Life Sciences Suwon
Experience 02
Postdoctoral Researcher2025–2026
Nakdong Univ. Wonju College of Medicine Physiology / Cellular Systems Research Center
Deep-learning multimodal-integration models fusing imaging, transcriptomic, and clinical data into single predictive models.
Associate Director2023–2025
Meridian Immune Therapeutics Inc. Basic Research, Seoul
Built in-house single-cell & spatial transcriptomics code from scratch; led NHP (cynomolgus, marmoset) EAE/MS multi-omic studies; oversaw regulatory documentation for an anti-CD25 humanized-antibody program.
Researcher2019–2021
Xenotransplantation Research Center, HNU Seoul
Rhesus macaque tissue processing, longitudinal immune monitoring, CNS tissue handling.
Research Student, MOSAIC2020–2023
Multi-Organ Single-cell Atlas of Immune Cells, HNU Genomic Medicine Institute
Founding proposal; executed within the funded program (500+ donors, 6 organs): milestone tracking, multi-site QC, multi-PI coordination.
Selected Publications 03
| 1 | Reyes M*, Skywalker L*, Alvarez T*, et al. "Conserved PDE9X short-isoform bias defines pathogenic Th1.17 state across human inflammatory diseases." Nature Immunology IF 27.7 under review. | 2026 |
| 2 | Skywalker L*, Tanaka Y*, Truong P*, et al. "Immune cell-enriched scRNA-seq unveils infiltrated CD8⁺ T resident memory cells and meningeal lymphatic endothelium in Parkinson's disease." J. Neuroimmunology IF 2.9. | 2025 |
| 3 | Skywalker L*, Delgado J*, Moreau S, et al. "Deciphering Dysfunctional Regulatory T Cells in Vitiligo." Allergy IF 12.6. | 2025 |
| 4 | Alvarez J*, Skywalker L*, et al. "Long-term control of diabetes by a baricitinib-based regimen after allo-islet transplantation in rhesus monkeys." Xenotransplantation IF 3.9. | 2024 |
| 5 | Novak L*, Skywalker L*, et al. "Intra-tumoral heterogeneity and immune escape of melanoma from chronic UV photodamage by spatial gene expression." JEADV IF 9.2. | 2022 |
| 6 | Skywalker L*, et al. "mTOR inhibitor-based immunosuppression in allogeneic islet transplantation." Islets IF 2.2. | 2019 |
| Co-author (selected): eBioMedicine (IF 11.1), JEADV (IF 9.2), Current Diabetes Reports (IF 4.2). | '21–'24 |
Technical Skills 04
Single-cell / spatial / multi-omicscRNA-seq, scTCR-seq, snRNA/snATAC; Seurat, Scanpy, Squidpy, Monocle3, CellChat/NicheNet; scVI/scANVI, consensus NMF; custom UMI-aware BAM-level isoform code (Python); Milo, GLIPH, InferCNV; GeoMx DSP; Olink proteomics.
Machine learning / DL / AIPython (scikit-learn, XGBoost/LightGBM/CatBoost, PyTorch); AUC-validated classifiers; VAE/GAN/GNN; multimodal DL (imaging + transcriptomic + clinical); AlphaFold2/3, ProteinMPNN, DiffDock; Linux, R, Git.
Experimental10x 5′/3′ scRNA + scTCR libraries; high-dimensional flow cytometry (24 markers); brain/CNS immune profiling; IHC/IF; two-photon; NHP CNS tissue (rhesus, cynomolgus, marmoset); EAE/MS & islet-transplant models.
Awards, Patents & Scholarships 05
Antagonistic Anti-CD25 Humanized Antibody (Patent)2024
Immunosuppression Composition w/ PI3K Inhibitor (Patent)2019
Grand Prize, AI Builders Hackathon (Project Nova)2024
Grand Prize, Metro Innovation Workathon2023
Best Poster, American Transplant Congress, Chicago2017
NRF Ph.D. Scholarship, BK21 Plus, HNU Dean's2014–2020
References 06
Min-Ho Suh, M.D., Ph.D.
HNU College of Medicine; CEO/CSO, Meridian Immune. Ph.D. advisor.
mhsuh@hangang.ac.krJi-Won Baek, M.D., Ph.D.
HNU, Microbiology & Immunology / IBRI. Computational co-corresponding.
jwbaek@hangang.ac.kr