Victor Von Doom, Ph.D.
Computational biologist · single-cell & spatial multi-omics into connectome-scale neuroscience
220 Harbor Street, Boston, MA 02135
T (555) 019-2847
E victor.vondoom@example.com
W victorvondoom.example.com/cv
T (555) 019-2847
E victor.vondoom@example.com
W victorvondoom.example.com/cv
Profile Objective
Moving from wet-lab immunology into computational neuroscience. I build methods that infer cellular identity, state, and interaction from large, incomplete single-cell and spatial data. Research objective: connect molecular cell identity to circuit structure and function by integrating connectomics with transcriptomics, growing into connectome-constrained circuit models.
Education Degree · Institution · Year
01
2014–2023
Ph.D., Biomedical Sciences
Hangang National University · Seoul, Republic of Korea
Mapping Dendritic Cell Heterogeneity Across Chronic Inflammatory Contexts · Advisor: Min-Ho Suh, M.D., Ph.D.
02
2012–2014
M.S., Biomedical Sciences
Hangang National University · Seoul
Enhanced LPS-Induced Monocyte Activation by Recombinant Human Soluble CD180
03
2008–2012
B.S., Genetic Engineering
Suwon Institute of Life Sciences · Suwon
Research & Professional Experience Role · Institution · Term
01
2025–2026
Postdoctoral Researcher
Nakdong University Wonju College of Medicine · Physiology / Cellular Systems Research Center
Developed deep-learning multimodal-integration models fusing imaging, transcriptomic, and clinical data into single predictive models.
02
2023–2025
Associate Director
Meridian Immune Therapeutics Inc. · Basic Research, Seoul
Built in-house single-cell & spatial transcriptomics analysis code from scratch; led cross-functional NHP (cynomolgus, marmoset) EAE/MS multi-omic studies; oversaw regulatory documentation for an anti-CD25 humanized-antibody program.
03
2021–2023
Manager, Basic Research
Meridian Immune Therapeutics Inc. · Seoul
04
2019–2021
Researcher
Xenotransplantation Research Center, HNU · Seoul
Rhesus macaque tissue processing, longitudinal immune monitoring, CNS (brain/spinal cord) tissue handling.
05
2020–2023
Research Student, MOSAIC
Multi-Organ Single-cell Atlas of Immune Cells, HNU · Genomic Medicine Institute
Contributed the founding proposal; executed within the funded program (500+ donors × 6 organs): milestone tracking, multi-site QC, multi-PI coordination.
Selected Publications First / co-first, bold = author
01
Reyes M*, Von Doom V*, Alvarez T*, et al. "Conserved PDE9X short-isoform bias defines pathogenic Th1.17 state across human inflammatory diseases." Nature Immunology IF 27.7 · under review, 2026. UMI-aware BAM-level isoform analysis; scRNA + scTCR + snATAC integration; ML classifier AUC 0.812; 702 samples, 251,055 CD4⁺ T cells.
02
Von Doom V*, Tanaka Y*, Truong P*, et al. "Immune cell-enriched scRNA-seq unveils infiltrated CD8⁺ T resident memory cells and meningeal lymphatic endothelium in Parkinson's disease." Journal of Neuroimmunology IF 2.9 · 2025. 9,240 cells, 8 immune populations.
03
Von Doom V*, Delgado J*, Moreau S, et al. "Deciphering Dysfunctional Regulatory T Cells in Vitiligo." Allergy IF 12.6 · 2025.
04
Alvarez J*, Von Doom V*, et al. "Long-term control of diabetes by a baricitinib-based regimen after allo-islet transplantation in diabetic rhesus monkeys." Xenotransplantation IF 3.9 · 2024.
05
Novak L*, Von Doom V*, et al. "Intra-tumoral heterogeneity and immune escape of melanoma arising from chronic UV photodamage by spatial gene expression profiling." JEADV IF 9.2 · 2022.
06
Von Doom V*, et al. "mTOR inhibitor-based immunosuppression in allogeneic islet transplantation." Islets IF 2.2 · 2019. Co-author: eBioMedicine (IF 11.1, 2024), JEADV (2024), Current Diabetes Reports (2021).
Technical Skills Domain · Detail
Single-cell / spatialscRNA-seq, scTCR-seq, snRNA/snATAC; Seurat, Scanpy, Squidpy, Monocle3, CellChat/NicheNet; scVI/scANVI, batch integration, consensus NMF, embedding geometry; custom UMI-aware BAM-level isoform code (Python); Milo, GLIPH, Shannon-entropy clonality, InferCNV, weighted-LMM/EMM; GeoMx DSP; Olink proteomics.
ML / DL / AIPython (scikit-learn, XGBoost/LightGBM/CatBoost, PyTorch); AUC-validated classifiers; VAE/GAN/GNN; multimodal DL integration (imaging + transcriptomic + clinical); vision-language transformers; AlphaFold2/3, ProteinMPNN, DiffDock, MolFormer; Linux servers, R/RStudio, Git.
Experimental10x 5′/3′ scRNA + scTCR libraries; high-dimensional flow cytometry (up to 24 markers), 10-color 6-way FACS; brain/CNS immune profiling; IHC/IF (frozen & FFPE); two-photon microscopy; NHP CNS tissue (rhesus, cynomolgus, marmoset); EAE/MS & islet-transplant models.
Awards, Patents & Scholarships Item · Year
Antagonistic Anti-CD25 Humanized Antibody (Patent)2024
Immunosuppression Composition w/ PI3K Inhibitor (Patent)2019
Grand Prize, AI Builders Hackathon (Project Nova)2024
Grand Prize, Metro Innovation Workathon2023
Best Poster, American Transplant Congress (Chicago)2017
NRF Ph.D. Scholarship · BK21 Plus · HNU Dean's2014–2020
References Name · Role · Contact
Min-Ho Suh, M.D., Ph.D.
Professor, HNU College of Medicine; CEO/CSO, Meridian Immune Therapeutics. Ph.D. advisor.
mhsuh@hangang.ac.krJi-Won Baek, M.D., Ph.D.
Assistant Professor, HNU Microbiology & Immunology / IBRI. Computational co-corresponding.
jwbaek@hangang.ac.krDae-Ho Yoon, Ph.D.
Professor, Physiology, Nakdong Wonju College of Medicine. Recent research supervisor.
dhyoon@nakdong.ac.kr