Ph.D., Biomedical Sciences2014–2023
Hangang National University · Seoul, Republic of Korea
Thesis: Mapping Dendritic Cell Heterogeneity Across Chronic Inflammatory Contexts. Advisor: Min-Ho Suh, M.D., Ph.D.
Curriculum Vitae
Otto Octavius, Ph.D. 제인 도
Computational biologist moving from single-cell & spatial multi-omics into connectome-scale neuroscience
220 Harbor Street, Boston, MA 02135(555) 019-2847otto.octavius@example.comGoogle Scholarottooctavius.example.com/cv
Profile
Moving from wet-lab immunology into computational neuroscience. I build methods that infer cellular identity, state, and interaction from large, incomplete single-cell and spatial data. Research objective: connect molecular cell identity to circuit structure and function by integrating connectomics with transcriptomics, growing into connectome-constrained circuit models.
Education
M.S., Biomedical Sciences2012–2014
Hangang National University · Seoul
Thesis: Enhanced LPS-Induced Monocyte Activation by Recombinant Human Soluble CD180.
B.S., Genetic Engineering2008–2012
Suwon Institute of Life Sciences · Suwon
Experience
Postdoctoral Researcher2025–2026
Nakdong University Wonju College of Medicine · Physiology / Cellular Systems Research Center
Developed deep-learning multimodal-integration models fusing imaging, transcriptomic, and clinical data into single predictive models.
Associate Director2023–2025
Meridian Immune Therapeutics Inc. · Basic Research, Seoul
Built in-house single-cell & spatial transcriptomics analysis code from scratch; led cross-functional NHP (cynomolgus, marmoset) EAE/MS multi-omic studies; oversaw regulatory documentation for an anti-CD25 humanized-antibody program.
Researcher2019–2021
Xenotransplantation Research Center, HNU · Seoul
Rhesus macaque tissue processing, longitudinal immune monitoring, CNS (brain/spinal cord) tissue handling.
Research Student · MOSAIC2020–2023
Multi-Organ Single-cell Atlas of Immune Cells, HNU · Genomic Medicine Institute
Contributed the founding proposal; executed within the funded program (500+ donors × 6 organs): milestone tracking, multi-site QC, multi-PI coordination.
Selected Publications Octavius O highlighted
1Reyes M*, Octavius O*, Alvarez T*, et al. "Conserved PDE9X short-isoform bias defines pathogenic Th1.17 state across human inflammatory diseases." Nature Immunology IF 27.7 · under review, 2026. UMI-aware BAM-level isoform analysis; scRNA + scTCR + snATAC integration; ML classifier AUC 0.812; 702 samples, 251,055 CD4⁺ T cells.
2Octavius O*, Tanaka Y*, Truong P*, et al. "Immune cell-enriched scRNA-seq unveils infiltrated CD8⁺ T resident memory cells and meningeal lymphatic endothelium in Parkinson's disease." J. Neuroimmunology IF 2.9 · 2025. 9,240 cells, 8 immune populations.
3Octavius O*, Delgado J*, Moreau S, et al. "Deciphering Dysfunctional Regulatory T Cells in Vitiligo." Allergy IF 12.6 · 2025.
4Alvarez J*, Octavius O*, et al. "Long-term control of diabetes by a baricitinib-based regimen after allo-islet transplantation in diabetic rhesus monkeys." Xenotransplantation IF 3.9 · 2024.
5Novak L*, Octavius O*, et al. "Intra-tumoral heterogeneity and immune escape of melanoma arising from chronic UV photodamage by spatial gene expression." JEADV IF 9.2 · 2022.
6Octavius O*, et al. "mTOR inhibitor-based immunosuppression in allogeneic islet transplantation." Islets IF 2.2 · 2019.
Co-author, selected: eBioMedicine (IF 11.1, 2024); JEADV (IF 9.2, 2024); Current Diabetes Reports (IF 4.2, 2021).
Technical Skills
Single-cell, spatial, multi-omic. scRNA-seq, scTCR-seq, snRNA/snATAC; Seurat, Scanpy, Squidpy, Monocle3, CellChat/NicheNet; scVI/scANVI, batch integration, consensus NMF; custom UMI-aware BAM-level isoform code (Python); Milo, GLIPH, InferCNV; GeoMx DSP; Olink proteomics.
Machine learning, DL, AI. Python (scikit-learn, XGBoost/LightGBM/CatBoost, PyTorch); AUC-validated classifiers; VAE/GAN/GNN; multimodal DL (imaging + transcriptomic + clinical); AlphaFold2/3, ProteinMPNN, DiffDock; Linux, R, Git.
Experimental. 10x 5′/3′ scRNA + scTCR libraries; high-dimensional flow cytometry (24 markers); brain/CNS immune profiling; IHC/IF; two-photon microscopy; NHP CNS tissue (rhesus, cynomolgus, marmoset); EAE/MS & islet-transplant models.
Awards & Patents
- Patents
- 2024Antagonistic Anti-CD25 Humanized Antibody. No. 1020240091845.
- 2019Immunosuppression Composition Comprising PI3K Inhibitor. No. 1020143496217.
- Awards
- 2024Grand Prize, AI Builders Hackathon (Project Nova).
- 2023Grand Prize, Metro Innovation Workathon.
- 2017Best Poster, American Transplant Congress, Chicago; Best Presentation, KAI.
- Scholarships
- 2014–20NRF Ph.D. Scholarship; HNU Dean's Lecture & Research; BK21 Plus.
References
Min-Ho Suh, M.D., Ph.D.Professor, Microbiology & Immunology / Biomedical Sciences, HNU; CEO/CSO, Meridian Immune. Ph.D. advisor.mhsuh@hangang.ac.kr
Ji-Won Baek, M.D., Ph.D.Assistant Professor, Microbiology & Immunology / IBRI, HNU. Computational co-corresponding.jwbaek@hangang.ac.kr
Dae-Ho Yoon, Ph.D.Professor, Physiology & Global Medical Science, Nakdong University Wonju College of Medicine. Recent supervisor.dhyoon@nakdong.ac.kr
English (native) · Korean (professional working proficiency).