Ph.D., Biomedical Sciences2014–2023
Hangang National University · Seoul, Republic of Korea
Mapping Dendritic Cell Heterogeneity Across Chronic Inflammatory Contexts. Advisor: Min-Ho Suh, M.D., Ph.D.
Lex Luthor, Ph.D.
Computational biologist · single-cell & spatial multi-omics into connectome-scale neuroscience
Loc Boston, MA 02135
Tel (555) 019-2847
Mail lex.luthor@example.com
Web lexluthor.example.com/cv
01Profile
Moving from wet-lab immunology into computational neuroscience. I build methods that infer cellular identity, state, and interaction from large, incomplete single-cell and spatial data. Research objective: connect molecular cell identity to circuit structure and function by integrating connectomics with transcriptomics, growing into connectome-constrained circuit models.
Scientific interests: single-cell & spatial multi-omics; cell-type inference from incomplete data; self-supervised / embedding representation learning; connectome × transcriptomics; computational neuroimmunology; reproducible ML/DL analysis.
02Education
M.S., Biomedical Sciences2012–2014
Hangang National University · Seoul
Enhanced LPS-Induced Monocyte Activation by Recombinant Human Soluble CD180.
B.S., Genetic Engineering2008–2012
Suwon Institute of Life Sciences · Suwon
03Experience
Postdoctoral Researcher2025–2026
Nakdong Univ. Wonju College of Medicine · Physiology / Cellular Systems Research Center
Developed deep-learning multimodal-integration models fusing imaging, transcriptomic, and clinical data into single predictive models.
Associate Director2023–2025
Meridian Immune Therapeutics Inc. · Basic Research, Seoul
Built in-house single-cell & spatial transcriptomics code from scratch; led cross-functional NHP (cynomolgus, marmoset) EAE/MS multi-omic studies; oversaw regulatory documentation for an anti-CD25 humanized-antibody program.
Manager, Basic Research2021–2023
Meridian Immune Therapeutics Inc. · Seoul
Researcher2019–2021
Xenotransplantation Research Center, HNU · Seoul
Rhesus macaque tissue processing, longitudinal immune monitoring, CNS (brain/spinal cord) tissue handling.
Research Student, MOSAIC2020–2023
Genomic Medicine Institute, HNU
Founding proposal contributor; executed within the funded program (500+ donors × 6 organs): milestone tracking, multi-site QC, multi-PI coordination.
04Publications
01
Reyes M*, Luthor L*, Alvarez T*, et al. "Conserved PDE9X short-isoform bias defines pathogenic Th1.17 state across human inflammatory diseases." Nature Immunology. AUC 0.812; 702 samples, 251,055 CD4⁺ T cells.
27.7rev '26
02
Luthor L*, Tanaka Y*, Truong P*, et al. "Immune cell-enriched scRNA-seq unveils CD8⁺ T resident memory cells and meningeal lymphatic endothelium in Parkinson's disease." J. Neuroimmunology. 11,587 cells.
2.92025
03
Luthor L*, Delgado J*, Moreau S, et al. "Deciphering Dysfunctional Regulatory T Cells in Vitiligo." Allergy.
12.62025
04
Alvarez J*, Luthor L*, et al. "Long-term control of diabetes by a baricitinib-based regimen after allo-islet transplantation in rhesus monkeys." Xenotransplantation.
3.92024
05
Novak L*, Luthor L*, et al. "Intra-tumoral heterogeneity and immune escape of melanoma arising from chronic UV photodamage by spatial gene expression." JEADV.
9.22022
06
Luthor L*, et al. "mTOR inhibitor-based immunosuppression in allogeneic islet transplantation." Islets.
2.22019
18 total17 peer-reviewed6 first / co-first1 under review
Co-author (selected): eBioMedicine (IF 11.1, 2024); JEADV (IF 9.2, 2024); Current Diabetes Reports (IF 4.2, 2021). * equal contribution.
05Technical Skills
Single-cell / spatial / multi-omic. scRNA-seq, scTCR-seq, snRNA/snATAC; Seurat, Scanpy, Squidpy, Monocle3, CellChat/NicheNet; scVI/scANVI, batch integration, consensus NMF; custom UMI-aware BAM-level isoform code (Python); Milo, GLIPH, InferCNV, weighted LMM/EMM; GeoMx DSP; Olink proteomics.
Machine learning / DL / AI. Python (scikit-learn, XGBoost/LightGBM/CatBoost, PyTorch); AUC-validated classifiers; VAE/GAN/GNN; multimodal DL (imaging + transcriptomic + clinical); AlphaFold2/3, ProteinMPNN, DiffDock, MolFormer; Linux, R/RStudio, Git.
Experimental. 10x 5′/3′ scRNA + scTCR libraries; high-dimensional flow cytometry (24 markers); brain/CNS immune profiling; IHC/IF; two-photon; NHP CNS tissue (rhesus, cynomolgus, marmoset); EAE/MS & islet-transplant models.
06Awards & Patents
Antagonistic Anti-CD25 Humanized Antibody (Patent)2024
Immunosuppression Composition w/ PI3K Inhibitor (Patent)2019
Grand Prize, AI Builders Hackathon (Project Nova)2024
Grand Prize, Metro Innovation Workathon2023
Best Poster, American Transplant Congress, Chicago2017
NRF Ph.D. Scholarship · BK21 Plus · HNU Dean's2014–2020
07References
Min-Ho Suh, M.D., Ph.D.
Professor, HNU College of Medicine; CEO/CSO, Meridian Immune. Ph.D. advisor. mhsuh@hangang.ac.kr
Ji-Won Baek, M.D., Ph.D.
Assistant Professor, Microbiology & Immunology / IBRI, HNU. Computational co-corresponding. jwbaek@hangang.ac.kr
Dae-Ho Yoon, Ph.D.
Professor, Physiology, Nakdong Wonju. Recent supervisor. dhyoon@nakdong.ac.kr
English (native) · Korean (professional working proficiency) · Selected presentations available on request