Ph.D., Biomedical Sciences
2014–2023
Hangang National University · Seoul, Korea
Mapping Dendritic Cell Heterogeneity Across Chronic Inflammatory Contexts. Advisor: Min-Ho Suh, M.D., Ph.D.
Diana Prince, Ph.D.
Computational single-cell & spatial multi-omics, moving toward connectome-scale neuroscience
Profile
Moving from wet-lab immunology into computational neuroscience. I build methods that infer cellular identity, state, and interaction from large, incomplete single-cell and spatial data. My research objective is to connect molecular cell identity to circuit structure and function by integrating connectomics with transcriptomics, growing into connectome-constrained circuit models.
Education
M.S., Biomedical Sciences
2012–2014
Hangang National University · Seoul
Enhanced LPS-Induced Monocyte Activation by Recombinant Human Soluble CD180.
B.S., Genetic Engineering
2008–2012
Suwon Institute of Life Sciences · Suwon
Research & Experience
Postdoctoral Researcher
2025–2026
Nakdong Univ. Wonju College of Medicine · Physiology / OMRC
Developed deep-learning multimodal-integration models fusing imaging, transcriptomic, and clinical data into single predictive models.
Associate Director, Basic Research
2023–2025
Meridian Immune Therapeutics Inc. · Seoul
Built in-house single-cell and spatial transcriptomics code from scratch; led cross-functional NHP (cynomolgus, marmoset) EAE / MS multi-omic studies; oversaw regulatory documentation for an anti-CD25 humanized-antibody program.
Researcher, Xenotransplantation Center
2019–2021
Hangang National University · Seoul
Rhesus macaque tissue processing, longitudinal immune monitoring, CNS (brain / spinal cord) tissue handling.
Research Student, MOSAIC Immune Atlas
2020–2023
Genomic Medicine Institute, HNU · Seoul
Founding proposal contributor; executed within the funded program (500+ donors × 6 organs): milestone tracking, multi-site QC, multi-PI coordination.
Selected Publications
1Reyes M*, Prince D*, Alvarez T*, et al. "Conserved PDE9X short-isoform bias defines pathogenic Th1.17 state across human inflammatory diseases." Nature Immunology IF 27.7 · under review, 2026. UMI-aware BAM-level isoform analysis; scRNA + scTCR + snATAC integration; ML classifier AUC 0.812; 702 samples, 251,055 memory CD4⁺ T cells.
2Prince D*, Tanaka Y*, Truong P*, et al. "Immune cell-enriched scRNA-seq unveils infiltrated CD8⁺ T resident memory cells and meningeal lymphatic endothelial cells in Parkinson's disease." Journal of Neuroimmunology IF 2.9 · 2025. 9,240 cells, 8 immune populations.
3Prince D*, Delgado J*, Moreau S, et al. "Deciphering Dysfunctional Regulatory T Cells in Vitiligo." Allergy IF 12.6 · 2025.
4Alvarez J*, Prince D*, et al. "Long-term control of diabetes by a baricitinib-based regimen after allo-islet transplantation in diabetic rhesus monkeys." Xenotransplantation IF 3.9 · 2024.
5Novak L*, Prince D*, et al. "Intra-tumoral heterogeneity and immune escape of melanoma arising from chronic UV photodamage by spatial gene expression profiling." JEADV IF 9.2 · 2022.
6Prince D*, et al. "mTOR inhibitor-based immunosuppression in allogeneic islet transplantation." Islets IF 2.2 · 2019.
Selected co-author: eBioMedicine (IF 11.1, 2024) · JEADV (IF 9.2, 2024) · Current Diabetes Reports (IF 4.2, 2021).
Technical Skills
Single-cell / spatial / multi-omic. scRNA / scTCR / snRNA / snATAC; Seurat, Scanpy, Squidpy, Monocle3, CellChat / NicheNet; scVI / scANVI, consensus NMF, embedding geometry; custom UMI-aware BAM-level isoform code (Python); Milo, GLIPH, InferCNV, weighted-LMM / EMM; GeoMx DSP; Olink proteomics.
ML / DL / AI. Python (scikit-learn, XGBoost / LightGBM / CatBoost, PyTorch); AUC-validated classifiers; VAE / GAN / GNN; multimodal DL (imaging + transcriptomic + clinical); AlphaFold2/3, ProteinMPNN, DiffDock, MolFormer; Linux, R / RStudio, Git.
Experimental. 10x 5′/3′ scRNA + scTCR libraries; high-dimensional flow (24 markers); brain / CNS immune profiling; IHC / IF; two-photon microscopy; NHP CNS tissue (rhesus, cynomolgus, marmoset); EAE / MS & islet-transplant models.