Ph.D., Biomedical Sciences
2014 – 2023
Hangang National University · Seoul, Republic of Korea
Mapping Dendritic Cell Heterogeneity Across Chronic Inflammatory Contexts · Advisor: Min-Ho Suh, M.D., Ph.D.
Curriculum Vitae
Hannibal Lecter, Ph.D.
Computational single-cell & spatial multi-omics · moving toward connectome-scale neuroscience
220 Harbor Street, Boston, MA 02135·(555) 019-2847
hannibal.lecter@example.com·Google Scholar·hanniballecter.example.com/cv
hannibal.lecter@example.com·Google Scholar·hanniballecter.example.com/cv
Profile
Moving from wet-lab immunology into computational neuroscience. I build methods that infer cellular identity, state, and interaction from large, incomplete single-cell and spatial data. My research objective is to connect molecular cell identity to circuit structure and function by integrating connectomics with transcriptomics, growing into connectome-constrained circuit models.
Education
M.S., Biomedical Sciences
2012 – 2014
Hangang National University · Seoul
Enhanced LPS-Induced Monocyte Activation by Recombinant Human Soluble CD180 · Advisor: Min-Ho Suh, M.D., Ph.D.
B.S., Genetic Engineering
2008 – 2012
Suwon Institute of Life Sciences · Suwon
Research & Professional Experience
Postdoctoral Researcher
2025 – 2026
Nakdong University Wonju College of Medicine · Physiology / Cellular Systems Research Center
Developed deep-learning multimodal-integration models fusing imaging, transcriptomic, and clinical data into single predictive models.
Associate Director, Basic Research
2023 – 2025
Meridian Immune Therapeutics Inc. · Seoul
Built in-house single-cell and spatial transcriptomics analysis code from scratch; led cross-functional NHP (cynomolgus, marmoset) EAE / multiple-sclerosis multi-omic studies; oversaw regulatory documentation for an anti-CD25 humanized-antibody program.
Researcher, Xenotransplantation Research Center
2019 – 2021
Hangang National University · Seoul
Rhesus macaque tissue processing, longitudinal immune monitoring, and CNS (brain / spinal cord) tissue handling.
Research Student, MOSAIC Multi-Organ Single-cell Atlas of Immune Cells
2020 – 2023
Genomic Medicine Institute, HNU · Seoul
Contributed the founding proposal; executed within the funded program (500+ donors × 6 organs): milestone tracking, multi-site QC, multi-PI coordination.
Selected Publications
1Reyes M*, Lecter H*, Alvarez T*, et al. "Conserved PDE9X short-isoform bias defines pathogenic Th1.17 state across human inflammatory diseases." Nature Immunology IF 27.7 · under review, 2026. UMI-aware BAM-level isoform analysis; scRNA + scTCR + snATAC integration; ML classifier AUC 0.812; 702 samples, 251,055 memory CD4⁺ T cells.
2Lecter H*, Tanaka Y*, Truong P*, et al. "Immune cell-enriched scRNA-seq unveils the interplay between infiltrated CD8⁺ T resident memory cells and meningeal lymphatic endothelial cells in Parkinson's disease." Journal of Neuroimmunology IF 2.9 · 2025. 9,240 cells, 8 immune populations.
3Lecter H*, Delgado J*, Moreau S, et al. "Deciphering Dysfunctional Regulatory T Cells in Vitiligo." Allergy IF 12.6 · 2025.
4Alvarez J*, Lecter H*, et al. "Long-term control of diabetes by a baricitinib-based immunosuppressive regimen after allo-islet transplantation in diabetic rhesus monkeys." Xenotransplantation IF 3.9 · 2024.
5Novak L*, Lecter H*, et al. "Intra-tumoral heterogeneity and immune escape of melanoma arising from chronic UV photodamage revealed by spatial gene expression profiling." JEADV IF 9.2 · 2022.
6Lecter H*, et al. "mTOR inhibitor-based immunosuppression in allogeneic islet transplantation." Islets IF 2.2 · 2019.
Selected co-author: eBioMedicine (IF 11.1, 2024) · JEADV (IF 9.2, 2024) · Current Diabetes Reports (IF 4.2, 2021).
Technical Skills
Single-cell / spatial / multi-omic. scRNA-seq, scTCR-seq, snRNA / snATAC; Seurat, Scanpy, Squidpy, Monocle3, CellChat / NicheNet; scVI / scANVI, batch integration, consensus NMF, embedding geometry; custom UMI-aware BAM-level isoform code (Python); Milo KNN-graph DA, GLIPH, Shannon-entropy clonality, InferCNV, weighted-LMM / EMM; GeoMx DSP (WTA + TCR); Olink targeted plasma proteomics.
Machine learning / deep learning / AI. Python (scikit-learn, XGBoost / LightGBM / CatBoost, PyTorch); AUC-validated classifiers; VAE / GAN / GNN; multimodal DL integration (imaging + transcriptomic + clinical); vision-language transformers; AlphaFold2/3, ProteinMPNN, DiffDock, MolFormer; Linux servers, R / RStudio, Git-based reproducible analysis.
Experimental (domain ground truth). 10x 5′/3′ scRNA + scTCR library generation; high-dimensional flow cytometry (up to 24 markers), 10-color 6-way FACS; brain / CNS immune profiling (perfusion, digestion, Percoll, CD45⁺ FACS); IHC / IF (frozen & FFPE); two-photon microscopy; NHP CNS tissue (rhesus, cynomolgus, marmoset); EAE / MS & islet-transplant disease models.
Awards, Patents & Scholarships
Patent · Antagonistic Anti-CD25 Humanized Antibody2024
Patent · Immunosuppression Composition w/ PI3K Inhibitor2019
Grand Prize, AI Builders Hackathon (Project Nova)2024
Grand Prize, Metro Innovation Workathon2023
Best Poster, American Transplant Congress, Chicago2017
NRF Ph.D. Scholarship · BK21 Plus · HNU Dean's2014–20
References
Min-Ho Suh, M.D., Ph.D.
Professor, HNU College of Medicine; CEO/CSO, Meridian Immune. Ph.D. advisor.
mhsuh@hangang.ac.krJi-Won Baek, M.D., Ph.D.
Assistant Professor, Microbiology & Immunology / IBRI, HNU. Computational co-corresponding.
jwbaek@hangang.ac.krDae-Ho Yoon, Ph.D.
Professor, Physiology, Nakdong Wonju. Most recent research supervisor.
dhyoon@nakdong.ac.krHannibal Lecter · Curriculum Vitae · Korean (native) · English (professional)